In the context of e-publishing, to arrange and visually design the text of an e-book.

The process of typesetting an e-book includes selecting typefaces, setting rules for normal body text (such as alignment, line spacing, and handling of breaks, widows and orphans), and visually designing special text such as headers or block quotes.

The person typesetting an e-book must take into consideration several factors that do not exist in print publishing: reflowable layout, the night-time reading mode available in some e-reading environments, and the user's ability to override various text settings.